Buy Epithalon (Epitalon) – Peptide Partners

Product Overview & Specifications

Epithalon, also written as Epitalon, is a synthetic short research peptide supplied by Peptide Partners for in-vitro testing, laboratory experimentation, cellular-aging research, and preclinical investigation.

Published studies have examined Epitalon in mouse oocyte culture, human gingival mesenchymal stem-cell systems, and aging skin-fibroblast cultures. Research topics include mitochondrial activity, reactive oxygen species, apoptosis-related markers, neurogenic gene expression, extracellular-matrix remodeling, cell proliferation, and cellular-aging pathways.

These findings are limited to laboratory cell and tissue models and do not establish human safety, anti-aging effects, fertility outcomes, neuroregenerative activity, or clinical efficacy. Researchers should review the applicable batch documentation and certificate of analysis before beginning any experiment.

Product Specifications

The stated 99.86% purity is based on multi-vial testing. Researchers should review the batch-specific certificate of analysis before beginning any experiment.

Primary Research Studies & Findings

Epitalon Protects Against Post-Ovulatory Aging-Related Damage of Mouse Oocytes In Vitro

Authors: Xue Yue, Sai-Li Liu, Jia-Ni Guo, Tie-Gang Meng, Xin-Ran Zhang, Hong-Xia Li, Chun-Ying Song, Zhen-Bo Wang, Heide Schatten, Qing-Yuan Sun, and Xing-Ping Guo

Publication: Aging, 2022;14(7):3191–3202

DOI: 10.18632/aging.204007

Reference: PubMed 35413689

This in-vitro study examined Epitalon in a mouse-oocyte post-ovulatory-aging model. Epitalon was added to the culture medium, and oocyte quality was assessed after 6, 12, and 24 hours of in-vitro aging.

Under the tested conditions, Epitalon treatment was associated with reduced intracellular reactive oxygen species, fewer spindle defects, and less abnormal cortical-granule distribution. The study also reported increased mitochondrial membrane potential and mitochondrial DNA copy number, together with reduced apoptosis at the 24-hour assessment point.

The authors proposed that the observed cellular effects were associated with modulation of mitochondrial activity and oxidative-stress levels in the cultured oocytes.

Plain-English Research Summary

This was a controlled laboratory study using cultured mouse oocytes. Epitalon was associated with changes in oxidative-stress, mitochondrial, and cell-structure markers during post-ovulatory aging in vitro. The results are limited to a mouse-cell model and do not establish human fertility effects or clinical outcomes.

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis During Neurogenesis: Possible Epigenetic Mechanism

Authors: V. Khavinson, F. Diomede, E. Mironova, N. Linkova, S. Trofimova, O. Trubiani, S. Caputi, and B. Sinjari

Publication: Molecules, 2020

Reference: PubMed 32019204

This study investigated the AEDG peptide, identified in the publication as Epitalon, in human gingival mesenchymal stem cells. The researchers examined gene expression, protein synthesis, and markers associated with neurogenic differentiation.

The study reported increased expression or synthesis of several neurogenic markers, including Nestin, GAP43, β-tubulin III, and Doublecortin. Molecular-modeling analyses suggested a possible interaction between AEDG and regions of histone H1 involved in DNA organization, providing a proposed epigenetic explanation for the observed changes.

The proposed mechanism was based on cell experiments and molecular modeling. Additional research would be needed to determine whether the reported marker changes correspond to functional neuronal differentiation or reproduce in other experimental systems.

Plain-English Research Summary

This cell-based study examined whether Epitalon-related AEDG peptide exposure altered markers associated with early neurogenic differentiation. The researchers observed changes in several gene-expression and protein markers and proposed a possible chromatin-related mechanism. These findings are mechanistic and laboratory-based and do not establish neuroregenerative activity in humans.

Peptide Regulation of Skin Fibroblast Functions During Their Aging In Vitro

Authors: N. Lin’kova, A. Drobintseva, O. Orlova, E. Kuznetsova, V. Polyakova, I. Kvetnoy, and V. Khavinson

Publication: Bulletin of Experimental Biology and Medicine, 2016

Reference: PubMed 27259496

This in-vitro study examined several short peptides, including AEDG, in aging skin-fibroblast cultures. The researchers assessed markers associated with proliferation, cellular aging, apoptosis, extracellular-matrix remodeling, and fibroblast function.

Across the peptide treatments, the authors reported reduced MMP-9 synthesis and increased Ki-67 and CD98hc expression. For AED and AEDG, the study also reported suppression of caspase-dependent apoptosis that had increased during the aging of the fibroblast cultures.

These findings characterize changes in cultured fibroblast markers under the study conditions. They do not demonstrate cosmetic, rejuvenating, wound-healing, or therapeutic effects in humans.

Plain-English Research Summary

This laboratory study tested short peptides in aging skin-fibroblast cultures. AEDG was associated with changes in markers related to cell proliferation, matrix remodeling, and programmed-cell-death signaling. The results may be relevant to cellular-aging research but do not establish a human skin benefit or clinical application.

Standard Research Disclaimer

Research Use Only. Not for use in diagnostic tests.

This product is solely intended for research purposes as a chemical compound. It is designated exclusively for in-vitro testing and laboratory experimentation. All information provided about this product is educational and should be evaluated by appropriately qualified research personnel.

By law, bodily introduction of this product into humans or animals is strictly prohibited. This compound must not be used, administered, or represented as a drug, food, dietary supplement, cosmetic, fertility product, anti-aging product, diagnostic material, or medical treatment. It is not intended to diagnose, treat, cure, or prevent any disease. It should be handled only by licensed and qualified professionals in an appropriately equipped laboratory and in accordance with applicable laws, institutional procedures, and relevant safety requirements.